Regulatory factor linked to late-onset diabetes?

Article Abstract:

The protein encoded by the gene pdx-1, which encodes a transcription factor for the insulin gene and controls pancreatic development, is needed for glucose homeostasis in the adult pancreas. It has been established that mice heterozygous for the gene pdx-1 have impaired glucose tolerance. In humans, a deficiency in pdx-1 could be responsible for a predisposition to the development of late-onset diabetes, especially against a background of other genetic mutations within the insulin-signalling cascade.

Elderly, Diabetes mellitus, Diabetes in old age

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The road not taken

Article Abstract:

Two studies of somatotrophs in the pituitary gland of dwarf mice clarify the role of extracellular signals in cell ontogeny. An inherited mutation of the growth-hormone-releasing factor (GRF) receptor gene causes somatotroph hypoplasia and dwarfism, indicating that GRF is both a hypothalamic-releasing hormone and a trophic factor. Lactotrophs do not express GRF receptors, so other regulatory factors must come into play after their bifurcation from somatotrophs.

Physiological aspects, Somatotropin releasing hormone, Somatotropin-releasing hormone, Dwarfism

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CREB controls hepatic lipid metabolism through nuclear hormone receptor PPAR-gamma

Article Abstract:

The mice deficient in CREB activity has a fatty liver phenotype and display elevated expression of the nuclear hormone receptor PPAR-gamma. CREB inhibits hepatic PPAR-gamma expression in the fasted state by stimulating the expression of the Hairy Enhancer of Split (HES-1) gene.

Health aspects, Cyclic adenylic acid, Cyclic adenosine monophosphate, Fasting

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