Repeated cocaine exposure in vivo facilitates LTP induction in midbrain dopamine neurons

Article Abstract:

A report that following repeated exposure to cocaine in vivo, excitatory synapses to rat ventral tegmental area (VTA) dopamine neurons become highly susceptible to the induction of long-term potentiation (LTP) by correlated pre- and postsynaptic activity is presented. This facilitated LTP induction is caused by cocaine-induced reduction of GABA(sub A) receptor-mediated inhibition of these dopamine neurons.

Science & research, Cocaine, Health aspects, Analysis, Physiological aspects, Rats, Electrophysiology, Rattus

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Distributed synaptic modification in neural networks induced by patterned stimulation

Article Abstract:

Paired-pulse stimulation of one neuron carried out repeatedly for short periods causes specific polysynaptic pathways to be weakened or reinforced in a way which is dependent on the interpulse interval. Temporal information can be stored as spatially distributed patterns of synaptic adaptations in a neural network.

Computer networks, Neural networks, Neurons

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