Requirement for Drosophila cytoplasmic tropomyosin in oskar mRNA localization
Article Abstract:
The localization of oskar (osk) RNA at the posterior pole of the Drosophila oocyte requires the activity of the tropomyosin II (TmII) gene. Female flies containing mutant TmII(super gs1) grow into sterile adults. Germ cell formation is affected by TmII mutation because of defective localization or maintenance of pole plasm molecules at the posterior pole. Reproductive induction precursors of the germ cells are not formed due to defective accumulation of osk RNA. Mutant TmII exerts its effect probably by inhibiting cTm protein and in turn impairing the linking of osk RNA to microtubules.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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Polarization of both major body axes in Drosophila by gurken-torpedo signalling
Article Abstract:
Gurken is essential in the germ line and torpedo/DER in the follicle cells to produce anterior-posterior polarity in the Drosophila by moving the oocyte to the posterior of the egg chamber and causing adjacent somatic follicle cells to acquire posterior fate. The evidence shows that the same germ line is used to form both the anterior-posterior and dorsal-ventral axes, suggesting the existence of distinct polar follicle cells that are differentiated before induction to respond to different signals.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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New role for tropomyosin
Article Abstract:
A study of the formation of the anterior-posterior axis in Drosophila embryos shows that the movement of oskar mRNA to the posterior axis requires the presence of a tropomyosin. This tropomyosin is not related to muscles and is present with the actin fibres. A mutation in the non-muscle tropomyosin inhibits the movement of oskar. Tropomyosin probably delivers oskar to the microtubules which transport it to the posterior end of the embryo.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
User Contributions:
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