Molecular mechanism of cAMP modulation of HCN pacemaker channels

Article Abstract:

It has been established that the C-terminal cyclic nucleotide-binding domain (CNBD) presents HCN channel gating and that cAMP binding relieves this inhibition. It is likely that the inhibitory action of the CNBD complex is linked to the core domain through the C linker.

Calcium channels, Binding sites (Biochemistry), Active sites (Biochemistry), Cations

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Role of H5 domain in determining pore diameter and ion permeation through cyclic nucleotide-gated channels

Article Abstract:

A narrow region of the channel pore, termed the selectivity filter, governs the ion permeation through membrane channels. It differentiates between ions by specific binding and molecular sieving. A study reveals that the H5 domain decides the pore diameter in controlling ion permeation. The H5 domain provides structural proof of the cyclic nucleotide-gated channels belonging to the voltage-gated channel group.

Influence, Molecular sieves

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Allosteric activation and tuning of ligand efficacy in cyclic-nucleotide-gated channels

Article Abstract:

Neural research shows a cyclic allosteric mechanism activates the retinal and olfactory cyclic-nucleotide-gated channels in ligand-independent and ligand-dependent channel openings. An amino-terminal domain other than the pore and ligand-binding motifs is involved in the allosteric gating transition which in turn tunes the physiological response of ligand-binding proteins in biological signals.

Neurobiology, Eye, Allosteric proteins

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