Role of interactions between the origin recognition complex and SIR1 in transcriptional silencing

Article Abstract:

A chromatin structure formed due to the interaction of the origin recognition complex (ORC) with SIR1 protein helps in transcriptional silencing of the HM mating-type loci in Saccharomyces cerevisiae. The SIR1 binds to the ORC1 during the S phase of the cell cycle. The protein SIR1 binds SIR4, bringing it nearer to SIR3 which is bound to RAP1. The interactions of SIR3 and SIR4 with the N-terminus tails of histones H3 and H4 collects the nucleosomes to form heterochromatin structure.

Research, Chromatin, Genetic regulation, Genetic transcription, Transcription (Genetics), Saccharomyces

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A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A

Article Abstract:

Exogenous expression of p300/CBP-associated factor (P/CAF) in HeLa cells suppresses the progression through the cell-cycle and opposes the mitogenic activity of the adenoviral oncoprotein E1A. E1A activates cell-cycle progression by binding to the p300/CBP and retinoblastoma gene family products. The P/CAF has intrinsic histone acetylase activity. E1A disrupts the normal cellular interaction between p300/CBP and P/CAF.

Analysis, Protein binding, Adenoviruses

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