Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor FcgammaRIIB

Article Abstract:

Inhibitory signalling by the Fc receptor, FcgammaRIIB, proceeds without the involvement of the SH2-domain containing protein tyrosine phosphatase, SHP-1, in the mast cells. This results in the attachment of the SH2-domain containing inositol polyphosphate 5-phosphatase or SHIP to the tyrosine-phosphorylated 13-amino-acid of Fcgamma RIIB in both B-cells and mast cells. The hydrolysis of 5-phosphate of phosphatidylinositol/inositol gives a mechanism for the FcgammaRIIB inhibition of calcium influx triggered by immune receptors.

Analysis, Observations, Immunology, B cells, Cell receptors, Immune system, Mast cells

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Augmented humoral and anaphylactic responses in Fc(gamma)RII-deficient mice

Article Abstract:

Weaknesses in the low-affinity immuno-globulin-G receptor Fc(gamma)RII or its signalling pathway in B cells upset the immune-complex-mediated feedback inhibition of the generation of antibodies. A study shows that the immunoglobulin levels of mice lacking in Fc(gamma)RII soar in reaction to antigens regardless of the latter's thymus-dependence. Findings indicate that Fc(gamma)RII negatively regulates immune-complex-triggered activation in vivo for the afferent as well as the efferent limbs of the immune reaction.

Immunoglobulin G, Anaphylaxis, Immune complexes

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Influenza virus receptors in the human airway

Article Abstract:

An anatomical difference in the distribution in the human airway of the different binding molecules preferred by the avian and human influenza viruses is demonstrated. Findings provide a rational explanation for why H5N1 viruses rarely infect and spread between humans although they can replicate efficiently in the lungs.

United States, Science & research, Health aspects, Risk factors, Development and progression, Influenza, Influenza viruses

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