Meet the stripped down rat

Article Abstract:

Michael Shuler is a chemical engineer at Cornell University in Ithaca in New York worked to model how chemicals entering the body can be metabolized into more toxic forms. Within a year of his research he had created a prototype animal on a clip on a postage stamp sized silicon wafer that held cells from a rat's brain, heart and liver in different trenches linked by tiny fluid channels.

Executive changes & profiles, Officials and employees, Semiconductor wafers, Cornell University, Shuler, Michael

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DBC1 is a negative regulator of SIRT1

Article Abstract:

The downregulation of DBC1 (Deleted in Breast Cancer-1) expression, which activates the SIRT1-dependent inhibition of apoptosis induced by genotoxic stress, is described. The results provide insight into the regulation of SIRT1 and their significance in the molecular mechanism of ageing and cancer.

Genetic aspects, Observations, Gene expression

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Energy source of flagellar type III secretion

Article Abstract:

The significance of the proton motive force (PMF) in mediating the flagellar type III secretion in Salmonella enterica is discussed. The findings prove that the ATP hydrolysis is not required for such secretion.

Physiological aspects, Salmonella

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