Role of the thrombin receptor in development and evidence for a second receptor

Article Abstract:

The thrombin receptor is important for embryonic development and the cloned receptor is important in fibroblast signalling. A second platelet thrombin receptor is present and different thrombin receptors have different tissue-specific functions. A study reveals that fifty percent of mice whose thrombin receptor gene (tr) is disturbed survive without any bleeding disorders while the rest die. Tr(super -/-) fibroblasts fail to respond to thrombin though tr(super -/-) platelets respond.

Lectins, Embryology, Animal embryology, Mice as laboratory animals, House mouse

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A dual thrombin receptor system for platelet activation

Article Abstract:

Genetic research indicates that gene expression for receptor protease-activated receptor-3 (PAR3) plays a significant role in biochemical thrombin response. Experiments using PAR3-deficient mice are described. Evidence suggests that receptor PAR4 is involved in human platelet function. Platelet activation appears to be triggered by a two-receptor physiological mechanism involving PAR3 and PAR4.

Genetic aspects, Blood platelets, Thrombosis, Platelet activation

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Thrombin signalling and protease-activated receptors

Article Abstract:

Research is presented concerning the method used by coagulation protease thrombin to regulate the behavior of cells. The role of receptors which are activated by protease is discussed.

Proteases, Blood cells

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