STIM1 is a Ca(super 2+) sensor that activates CRAC channels and migrates from the Ca(super 2+) store to the plasma membrane
Article Abstract:
A demonstration that the expression of EF-hand mutants of Stim or STIM1 activates calcium-release-activated calcium (CRAC) channels constitutively without changing Ca(super 2+) store content is presented. The CRAC channels in T lymphocytes is the best-characterized store-operated calcium (SOC) influx channel and is essential to the immune response, sustained activity of CRAC channels being required for gene expression and proliferation.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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Phospholipase C(sub gama) activates Ras on the Golgi apparatus by means of RasGRP1
Article Abstract:
A study is conducted to show that, in response to Src-dependant activation of Phospholipase C(sub gama) 1, the Ras guanine nucleotide exchange factor RasGRP1 translocated to the Golgi where it activates Ras. The activation of Ras on Golgi has important biological consequences and proceeds through a pathway distinct from the one that activates Ras on the plasma membrane.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
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The role of presenilin cofactors in the gama secretase complex
Article Abstract:
It is shown that Drosophila APH-1 increases the stability of Drosophila presenilin holoprotein in the complex. Thus, APH-1 stabilizes the presenilin holoprotein in the complex, whereas PEN-2 is required for endoproteolytic processing of presenilin.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
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