Salt-resistant hypertension in mice lacking the guanylyl cyclase-A receptor for atrial natriuretic peptide

Article Abstract:

Disruption of the guanylyl cyclase-A (GC-A) receptor gene causes a chronic increase in blood pressure and affects peripheral resistance in mice fed on a normal salt diet. Atrial natriuretic peptide (ANP) combines with GC-A in the kidney to regulate natriuresis and diuresis. GC-A effects the vasculature level, independent of salt concentration. ANP enhances sodium excretion, reduces blood pressure and increases the concentration of c-GMP.

Hypertension, Cell receptors

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Swimming with sperm

Article Abstract:

Issues concerning research connecting calcium ion channels to sperm mobility and to ways of increasing levels of fertility are discussed. Particular attention is given to analyses of sperm movements and to extracellular information processed by sperm cells.

Cases, Cell research, Cytological research, Semen

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Structure of the dimerized hormone-binding domain of a guanylyl-cyclase-coupled receptor

Article Abstract:

Research is presented concerning the secretion of atrial natriuretic peptide hormone by the heart as a response to blood pressure increases. The crystalline structure of the glycosylated dimerized hormone-binding domain dimer is described.

Heart, Glycosylation, Letter to the Editor, Hormone research

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