Semi-conservative DNA replicatin through telomeres requires Taz1

Article Abstract:

Telomere-binding proteins have crucial roles in controlling telomerase activity but little is known about their role in controlling semi-conservative replication, which synthesizes the bulk of telomeric DNA. Telomere repeats in the fission yeast Schizosaccharomyces pombe are bound by Taz1, a regulator of diverse telomere functions and is generally assumed that telomere-binding proteins impede replication fork progression, but Taz1 is crucial for efficient replication fork progression through the telomere.

Telomeres, Binding proteins

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The mechanism of DNA replication primer synthesis by RNA polymerase

Article Abstract:

The RNA primers for DNA replication are usually synthesized by specialized enzymes, the primase but some replication system have evolved to use cellular DNA-dependent RNA polymerase for primer synthesis. The transcription complexes with similar topology may prime the replication of other bacterial mobile elements and may regulate transcription elongation under conditions that favor the formation of an extended RNA-DNA hybrid.

Petroleum Refineries, Petroleum refining, Polymerization, Observations, RNA interference

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Self-replication from random parts

Article Abstract:

The autonomous self-replication of a reconfigurable string of parts from randomly positioned input components is described. Such components, if suitably miniaturized and mass-produced, could constitute self-fabricating systems whose assembly is brought about by the parts themselves.

Design and construction, Technology application, Microelectromechanical systems, Automatic control

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