Signal-specific co-activator domain requirements for Pit-1 activation
Article Abstract:
The pituitary-specific factor POU-domain protein Pit-1 is a member of the homeodomain group of proteins, important in development and homeostasis. It is shown that Pit-1 activity is determined by a controlled balance between a co-repressor complex containing N-CoR/SMRT, mSin3A/B and histone deacetylases, as well as a co-activator complex including a CREB-binding protein (CPP). It is demonstrated that the change in specific requirements for histone acetyltransferases and CBP domains, mediates the effects of signal-transduction DNA-bound transcription factor pathways.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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Transcriptional regulation of a metastasis suppressor gene by Tip60 and beta-catenin complexes
Article Abstract:
The down-regulation of a metastasis suppressor gene, KAI1, in prostate cancer cells involves the inhibitory actions of beta-catenin, along with a reptin chromatin remodelling complex. The increased beta-catenin expression and recruitment of histone deacetylase activity is required for inhibiting the function of beta-catenin-reptin.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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