Slit, the midline repellent

Article Abstract:

The slit gene, one of many genes that affect the larval cuticle pattern in Drosophila, has a product which is believed to be important in the formation of the commissures, or seams, along which the axons that are sent by neurons across the midline of the central nervous system in bilaterally symmetric animals move. This product is also thought to be significant in axon guidance and the migration of muscle cells. It has been shown that Slit binds to roundabout (Robo) on cell surfaces and in solution. There are at least three forms of Slit in mammals, along with at least two of Robo.

Research, Cell receptors, Axonal transport

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Frizzled regulation of Notch signalling polarizes cell fate in the Drosophila eye

Article Abstract:

The Drosophila eye is highly polarized having mirror-image symmetry around the equator. R3 and R4 photoreceptors in each ommatidium are critical to polarity. It is shown that the transmembrane receptor Notch is needed downstream of dishevelled (dsh) gene in R3/R4 to adopt distinct fates. Notch becomes specifically activated in R4 and it is proposed that Fz/Dsh mediates activity of Notch ligand Delta, and restricts Notch receptor activity in R3.

Observations, Eye, Polarity (Biology)

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