Solution structure of the POU-specific DNA-binding domain of Oct-1

Article Abstract:

Nuclear magnetic resonance was used to determine the solution structure of the POU-specific DNA-binding domain of transcription factor Oct-1. Four alpha-helices are connected by short loops with helices I and IV in a parallel coiled-coil arrangement. There is an apparent similarity between the folding topology and that of the bacteriophage lambda-repressor and 434 repressor. Helix III appears to be the mediator in DNA-binding. A model for the POU-DNA complex is presented.

---

The sound of silence

Article Abstract:

A study of the role of ligand-dependent transcription factors in the absence of their ligands shows that these transcription factors silence basal transcription in these circumstances. They also behave as heterodimers and potent repressors with the reversed polarities. Silencing is achieved by these receptors to increase target-gene specificity of certain elements. The potential of these results in studying the physiological role of trans-repression is discussed.

---

Structural basis for DNA bending by the architectural transcription factor LEF-1

Article Abstract:

Minor groove binding and protein-induced DNA bending can be explored through the nuclear magnetic resonance exploration of the interaction between the lymphoid enhancer-binding factor (LEF-1) and a high-mobility-group (HMG) domain. The interaction structure shows the mechanism of the involvement of LEF-1 in the regulation of thymocyte differentiation and organogenesis.

T cell antigen receptors, T cells

Similar abstracts:

• Abstracts: Crystal structure at 1.7 A of the bovine papillomavirus-1 E2 DNA-binding domain bound to its DNA target
• Abstracts: Crystal structure at 1.7 A of the bovine papillomavirus-1 E2 DNA-binding domain bound to its DNA target. part 2
• Abstracts: Crystal structure of the tetramerization domain of the Shaker potassium channel. Cell-free expression of functional Shaker potassium channels
• Abstracts: Final listing rules approved for 21 species during July/October 1992. Fifty-six species added to list of threatened and endangered species in August-October 1991
• Abstracts: Inhibition of HIV-1 infectivity by zinc-ejecting aromatic C-nitroso compounds. Structural basis for packaging the dimeric genome of Moloney murine leukaemia virus

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.