Death of a T cell
Article Abstract:
Studies on the death of antigen receptor (TCR)-stimulated T-lineage cells suggest that their self-destruction is associated with activation of the cell surface receptor Fas, APO-1 or CD95. TCR activation induces the expression of CD95 and its ligand to cause death of T hybridoma cells, Jurkat T leukemia cells and non-transformed preactivated T cells. Inhibition or downregulation of the receptor and its ligand by cyclosporin A and glucocorticoids prevents cell death.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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Alternative pathways for the selection of antigen-specific peripheral T cells
Article Abstract:
T-cells present in the splenic germinal centers regain thymocyte-like sensitivity towards T-cell antigen receptors and steroid-induced apoptosis. They undergo antigen-driven selection of clonal survival and apoptosis. T-cell responses in the other parts of spleen lack programmed cell death. A differentiation pathway for the peripheral T-cells suggests that germinal centers induce a lymphocyte phenotype to maintain self-tolerance.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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