Structural basis of the alpha1-beta subunit interaction of voltage-gated Ca2+ channels:
Article Abstract:
The Ca2(super +) channels are high- voltage-activated and are essential for diverse biological processes, and the beta subunit interacts with alpha1 primarily through the beta-interaction domains (BID), which binds to the alpha interaction domain (AID). Ca+ channel beta-subunit contains two common protein -interaction domains and interacts with the alpha1 subunit not through the BID but through a hydrophobic groove in granylate kinase (GK).
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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Selection and evolution of enzymes from a partially randomized non-catalytic scaffold
Article Abstract:
New enzymatic activities are created de novo without the requirement for prior mechanistic information by selection from a naive protein library of very high diversity, with product formation as the sole selection criterion. The isolation of novel RNA ligases from a zinc finger scaffold has displayed multiple turnovers with rate enhancements of more than two-million-fold.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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Passing the torch
Article Abstract:
Francis Crick, who was responsible for discovering the double-helix structure of the DNA along with James Watson in 1953, was aware of the broader aspects and reach of biology. Francis Crick's essay in Nature magazine, which was published in 1970 called 'Molecular Biology in the Year 2000' is very close to the current scenario in molecular biology and genetics.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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