Structural biology: Molecular machinery in action

Article Abstract:

Nuclear magnetic resonance (NMR) spectroscopy is used to obtain the atomic motions in the 20S proteasome core particle (CP) in order to find how the proteasome performs its function of removing damaged and misfolded proteins from cells. The NMR technique has provided information about the internal dynamics and transient interactions of a variety of molecular machines, which when combined with X-ray diffraction will help in understanding the biomolecules' work at a molecular level.

Proteins, Atomic properties, Ubiquitin-proteasome system

---

Structure and mechanism of the M2 proton channel of influenza A virus

Article Abstract:

The NMR structural studies of the integral membrane protein M2 isolated from influenza virus, which forms pH-gated proton channels in the viral lipid envelope, are described. The findings provide insight into the tetrameric M2 channel in complex binding with rimantadine complex which increases the hydrophilicity of pore or helices packing to enhance the channel opening.

Physiological aspects, Protein binding, Influenza viruses

---

NMR down to Earth

Article Abstract:

Expensive superconducting magnets are not absolutely necessary to perform high-resolution nuclear magnetic response (NMR) spectroscopy, as per Stephan Appelt and his colleagues. They use a far less pricey source of magnetism, that is, Earth's own magnetic field to distinguish the chemical structures of various molecules containing hydrogen, lithium and fluorine.

All Other Miscellaneous Electrical Equipment and Component Manufacturing, Superconducting Magnets, Structure

Similar abstracts:

• Abstracts: IKKalpha limits macrophage NG-kB activation and contributes to the resolution of inflammation. Short-term memory
• Abstracts: Prospects for a vaccine against the Hepatitis C virus. Mechanism of action of interferon and ribavirin in treatment of Hepatitis C
• Abstracts: Comparative breeding ecology of Cooper's hawks in urban and exurban areas of southeastern Arizona. part 2 How do prey persist?
• Abstracts: Do all freshwater eels migrate? A new radiocarbon evolution and the dispersal of modern humans in Eurasia. Spawning of eels near a seamount
• Abstracts: No more protection. Enigmatic clouds illuminated. Think global

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.