Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors

Article Abstract:

The crystal structure of the ligand-binding domains of cognate nuclear orphan receptors, Nurr1, which lack identifiable ligands, exhibit a canonical protein fold and do not contain cavity in the region where ligands are localized. Nurr1 does not possess a binding site for coactivators but still capable of transcriptional activity in a ligand-independent manner.

Sweden, Analysis, Physiological aspects, Genetic transcription, Transcription (Genetics), Ligand binding (Biochemistry), Cell receptors, Structure-activity relationships (Biochemistry), Structure

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Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors

Article Abstract:

GPR91, a previously orphan G-protein-coupled receptor (GPCR), is shown to function as a receptor for the critic acid cycle intermediate succinate. The results show that succinate increases blood pressure in animals and indicate a possible role for GPR91 in renovascular hypertension.

All Other Basic Organic Chemical Manufacturing, Industrial Organic Chemicals, Succinates, Influence, Renovascular hypertension

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Orphan detectors of metabolism

Article Abstract:

The functions of many myriad G-protein-coupled receptor (GPCR) proteins in living organisms are unknown. Functions and the important uses of two newly discovered myriad G-protein-coupled receptor proteins are discussed.

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