SAGA interacting factors confine sub-diffusion of transcribed genes to the nuclear envelope

Article Abstract:

Dynamic three-dimensional tracking of a single locus in live yeast shows that the activation of GAL genes leads to a confinement in dynamic motility and that the GAL locus is subject to sub-diffusive movement, which after activation can become constrained to a two-dimensional sliding motion along the nuclear envelope. RNA-fluorescence in situ hybridization analysis after activation reveals a higher transcriptional activity for the peripherally constrained GAL genes than for loci remaining intranuclear.

Physiological aspects, RNA, Nuclear membranes, Nuclear membrane

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A switch for S phase

Article Abstract:

A seminal discovery about the identification of the protein factors from the budding yeast Saccharomyces cerevisiae that recognize the spots on DNA for initiating the DNA-replication phase of the cell cycle is reported. Phosphorylation is found to be at the heart of this intricate process, which is responsible for activation of two proteins known as Sld3 and Sld2 and the involvement of a third named Dpd11.

DNA replication

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