Structure of a glutamate-receptor ligand-binding core in complex with kainate

Article Abstract:

Ionotropic glutamate receptors play a major role in synaptic transmission in both vertebrates and invertebrates. Transmembrane ion channels are opened through ligands. These receptors play a major role in the way the nervous system develops and functions, and in learning and memory. They have been linked to a number of dysfunctions such as Huntington's disease, stroke, Parkinson's and epilepsy. New ligands can be designed using information on the crystal structure of a ligand-binding region using these receptors.

Ligands (Biochemistry), Cell receptors

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Functional characterization of a potassium-selective prokaryotic glutamate receptor

Article Abstract:

It has been established that the M1, P and M2 pore-forming regions in glutamate receptors (GluRs) and potassium channels have very similar structure. Differences are mainly limited to the selectivity filter region. The amino-acid sequence and functional relationships between GluR0, eukaryotic GluRs and KcsA provide backing for the hypothesis that all GluRs are tetrameric in subunit stoichiometry. It was found that the N-terminal domain is not vital for channel gating.

Potassium channels

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Structure of a glutamate transporter homologue from pyrococcus horikoshii

Article Abstract:

Glutamatergic synapses are the chemical synapse that mediates the majority of fast excitatory neurotransmission. Essential for normal development and function, the glutamatergic synapse is a linchpin for learning and memory, and dysfunction at these synapses is implicated in a wide range of nervous system diseases and injuries, including schizophrenia, depression, and stroke.

Science & research, Analysis, Causes of, Glutamate, Schizophrenia, Neural transmission, Synaptic transmission

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