Structure of a major immunogenic site on foot-and-mouth disease virus

Article Abstract:

A characterization of the structure of a major immunogenic site on foot-and-mouth disease virus (FMDV) is reported. A previous effort to characterize the crystal structure of FMDV was hampered by poor visibility of the Arg-Gly-Asp-containing loop which attaches the virus to its cellular receptor and which is also highly antigenic. The difficulty was resolved by reducing a particular disulphide bond which enabled the description of an unambiguous infective crystal structure. The correlation of this crystal structure to key biological properties of FMDV were presented and discussed.

Analysis, Structure-activity relationships (Biochemistry), Foot-and-mouth disease virus, Foot and mouth disease virus

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The crystal structure of bluetongue virus VP7

Article Abstract:

Viral structural proteins reveal a new type of molecular architecture, the crystal structure of VP7 found in bluetongue virus (BTV), an orbivirus gene of the Reoviridae family. The viruses possess a double-stranded segmented RNA genomic structure inside a capsid, with a VP2 outer layer and an alpha VP5 layer which is removed when the virus enters the host cell. The occurrence of VP7 is a strange phenomena in this virus and the VP7 strands are formed as trimers when the virus enters the host cell. The VP7 consists of two domains of alpha helices.

Viruses, Morphology (Biology), Reoviruses

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Crystal structure of SIV matrix antigen and implications for virus assembly

Article Abstract:

The crystal structure of simian immunodeficiency virus (SIV) matrix antigen (MA) indicates the formation of a trimer with many biological properties of MA. SIV is similar to the human immunodeficiency virus (HIV) and their matrix antigens are identical in about half of the sequences. MA is a part of the Pr55Gag protein that is necessary for assembly of the virion shell. MA helps in the incorporation of virus envelope protein and assembly of the Pr55Gag shell.

Proteins, Protein structure, Simian immunodeficiency virus

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