Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

Article Abstract:

Electrophoresis and biological assays of ceramide-mediated apoptosis reveal the resisting influence of sphingosine-1-phosphate (SPP) on intranucleosomal DNA fragmentation and morphological changes. SPP restrains the ceramide-induced activation of stress-activated protein kinase and successfully prevents serum deprivation-induced apoptosis in HL-60 cells. The stimulation of sphingosine kinase activates protein kinase C leading to a rise in intracellular SPP. The survival of the cell hinges on the balance between the intracellular levels of ceramide and SPP.

Usage, Cell death, Electrophoresis, Protein kinases, Biological assay, Bioassay

---

It's all relative

Article Abstract:

The researchers have detected three big genome duplications in the history of the plant Arabidopsis by constructing evolutionary trees of genes. The effect of genome duplication on the history of individual genes, is discussed.

United States, Science & research, Genomes, Arabidopsis

---

Similar abstracts:

• Abstracts: Repression of c-fos promoter by MyoD on muscle cell differentiation. Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein
• Abstracts: Specific repression of TATA-mediated but not initiator-mediated transcription by wild-type p53. A transcription factor controlling development of peripheral sense organs in C. elegans
• Abstracts: Evolution of cooperation in a finite homogeneous graph. Development with a bite. Parallel extinction risk and global distribution of languages and species
• Abstracts: Jarosite as an indicator of water-limited chemical weathering on mars. The devil is in the dust
• Abstracts: Permian tetrapods from the Sahara show climate-controlled endemism in Pangaea. A polydactylous amniote from the Triassic period

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.