Synaptic strengthening through activation of Ca(super 2+)-permeable AMPA receptors

Article Abstract:

Miniature excitatory postsynaptic current measurements on dorsal horn neurons in culture demonstrates the synaptic localization of Ca(super 2+)-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionate (AMPA) receptors on these neurons. Their activation increases the postsynaptic intracellular calcium ion concentration in neurites leading to short-term and long-term changes in synaptic strength in the central nervous system of vertebrates. The synaptic fluxes of AMPA receptors are prominent at negative membrane potentials.

Usage, Cell culture, Tissue culture, Neural receptors

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Kainate-receptor mediated sensory synaptic transmission in mammalian spinal cord

Article Abstract:

The excitatory neurotransmitter glutamate in the central nervous system activates receptors that gat ion channels. AMPA and NMDA receptors contribute to synaptic transmission and plasticity. In recent work the physiological function of kainate receptors has focused on the hippocampus. High-intensity single-shock simulation of primary afferent sensory fibres has been found to produce a fast, kainate-receptor-mediated excitatory postsynaptic current (EPSC) in the spinal cord.

Physiological aspects, Spinal cord

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Endophilin I mediates synaptic vesicle formation by transfer of arachidonate to lysophosphatidic acid

Article Abstract:

Transport of substances across cell membranes requires fission of the vesicle from its donor membrane and a subsequent merging with its acceptor membrane. The GTPase dynamin is implicated in membrane constriction and fission but it is believed to act indirectly via an unknown effector system. A new study shows that dynamin works with the presynaptic protein of unknown function, endophilin I, to mediate synaptic vesicle formation.

Lipid membranes

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