DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation

Article Abstract:

Mouse cells deficient for KU80 show a marked rise in chromosomal aberrations, such as breakage, aneuploidy, and translocations. It is concluded that Ku80 is a caretaker gene.

Chromosome abnormalities

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The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks

Article Abstract:

The ATM kinase activity and the repair pathway is shown to inhibit the RNA polymerase I (Pol I) transcription in the mouse cells in response to the chromosome and DNA breaks.

Science & research, RNA polymerases, Cell physiology

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Requirement for Ku80 in growth and immunoglobulin V(D)J recombination

Article Abstract:

The T and B lymphocyte development arrests in the early progenitor stage and V(D)J rearrangement is impaired in mice with Ku80 null mutations. The mutant mice are viable and fertile but are 40%-60% of the size of the unmutated control mice. The fibroblasts in the mutant embryo grow twice as slowly as their wild counterpart. The mutant cells are unable to enter the cell cycle if their DNA is damaged. The slow growth and reduced size of the mutant mice suggests a link between the Ku80 protein and growth control.

Physiological aspects, Gene mutations, Gene mutation, Proteins, Metabolic regulation, Growth, Growth (Physiology), Growth regulators

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