AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1
Article Abstract:
Overexpression of Forkhead transcription factors can cause growth suppression in cell lines, such as a Ras-transformed cell line.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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Forkhead transcription factors contribute to execution of the mitotic programme in mammals
Article Abstract:
It has been established that forkhead transcription factors regulate expression of mitotic genes like polo-like kinase. This work provides fresh evidence for the significant function of forkhead in the control of mammalian cell cycle completion.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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Direct control of the Forkhead transcription factor AFX by protein kinase B
Article Abstract:
AFX, a human orthologue of the Forkhead transcription factor daf-16, is phosphorylated by the phosphatidylinositol-3-OH-kinase effector protein kinase B. It has been established that the C-terminal part of AFX acts as a strong transcriptional transactivating domain. It is possible that the full-length AFX protein is needed for inhibition by insulin, as transcription by Gal4-C is not repressed by insulin and insulin can repress activity of Gal4-FL. It is clear that phosphorylation of the AFX transcription factor is one of the outcomes of protein kinase B relocalization.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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