The Caenorhabditis elegans genome sequencing project: first steps in automation

Article Abstract:

The development of an automated method for the genome sequencing of the nematode Caenorhabditis elegans is described. The automation of the C. elegans genome sequencing project allowed an appreciation of the scale of operation and the potential difficulties of large-scale genome sequencing using robotic systems. A robotic system was developed for plaque picking and growth, M13 DNA purification and DNA sequencing. The advantages of this robotic system over other molecular biology robots includes elimination of constant intervention by humans, high thoroughput and flexibility for future changes or improvements.

Usage, Genetic aspects, Technology application, Chromosome mapping, Caenorhabditis elegans, Robotics

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In vivo immunosuppression by targeting a novel protease receptor

Article Abstract:

Membrane receptors for blood proteinases control clotting and fibrinolytic cascades, signal transduction and the growth of mesenchymal cells. It is not clear whether the mechanisms in developing vascular injury take part in the production of an immune response. A new role for protease receptors in regulating immune response is derived. A potential target for therapeutic immunosuppression in humans is also identified.

Analysis, Proteases, Immunosuppression

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