The Gcn5 bromodomain co-ordinates nucleosome remodelling

Article Abstract:

The Gcn5 bromodomain is needed for nucleosome remodelling and transcriptional activation in stages subsequent to histone acetylation. The identical molecular and genetic phenotypes in both swi2 and bromodomain mutant strains indicate the existence of a stage requiring their coordinated function. Bromodomain residues vital for acetyl-lysine binding are not needed in vivo for Gcn5-mediated histone acetylation but are essential for the subsequent Swi2-dependent nucleosome remodelling and transcriptional activation.

Histones

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elF4E function in somatic cells modulates ageing in Caenorhabditis elegans

Article Abstract:

The loss of a specific eukaryotic initiation factor 4 E (eIF4E) isoform (IFE-2) functioning in somatic tissues has reduced global protein synthesis, protects from oxidative stress and has extended lifespan in Caenorhabditis elegans. IFE-2 deficiency has extended the lifespan of long-lived age and daf nematode mutants, whereas the lack of IFE-2 has enhanced the long-lived phenotype of clk and dietary-restricted eat mutant animals.

United States, Science & research, Protein synthesis, Caenorhabditis elegans, Protein biosynthesis, Oxidative stress

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The omnipotent nucleosome

Article Abstract:

Recent findings suggest that nucleosomes play a much more active role in transcription. In the 5S RNA in Xenopus, placement of a nucleosome on the 5S gene blocks binding of the transcription factor TFIIA. It is the amino-terminal regions of the histone molecule that is responsible for this binding. In addition, the relation between the post-translational modification process of acetylation and transcription was investigated.

Physiological aspects, Nucleoproteins, Xenopus

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