Two neurons mediate diet-restriction-induced longevity in C. elegans
Article Abstract:
Researchers have shown that increased longevity of diet-restricted Caenorhabditis elegans has required the transcription factor gene skn-1 acting in the ASIs, a pair of neurons in the head. The analysis has shown that increased lifespan in a diet-restricted metazoan has depended on cell non-autonomous signalling from central neuronal cells to non-neuronal body tissues and the ASI neurons have mediated diet-restriction-induced longevity by an endocrine mechanism.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans
Article Abstract:
A newly discovered, adult-specific function is described for the transcription factor PHA-4 in the regulation of diet-restriction-mediated longevity in Caenorhabditis elegans. It is shown that the role of PHA-4 in lifespan determination is specific for dietary restriction, as it is not needed for the increased longevity caused by other genetic pathways that regulate ageing.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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When less is more
Article Abstract:
The researchers have described the role of a pair of evolutionarily conserved proteins, PHA-4 and SKN-1, in conferring extended survival under dietary restriction in the small roundworm Caenorhabditis elegans. Evidence has indicated that these PHA-4 and SKN-1 transcription factors might also trigger hormones that coordinate physiological responses to dietary restriction.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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