A polycystic kidney-disease gene homologue required for male mating behaviour in C. elegans

Article Abstract:

It has been possible to identify a gene, lov-1 (for location of vulva), needed for mating response and vulva location in the Caenorhabditis elegans male. This gene encodes a putative membrane protein with a mucin-like, serine-threonine-rich amino terminus followed by two blocks of homology to human polycystins. It could act in a sensory signalling pathway, coupling voltage-activated signalling or store-operated conductance. Another possibility is that it acts as a molecular scaffold for other molecules in creating or maintaining neuronal cell polarity.

Genetic aspects, Polycystic kidney disease, Caenorhabditis elegans

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A C. elegans stretch receptor neuron revealed by a mechanosensitive TRP channel homologue

Article Abstract:

A study was conducted to show that Transient Receptor Potential (trp)-4 mutant worms bend their body abnormally, exhibiting a body posture distinct from that of wild-type worms during locomotion, suggesting that trp-4 is involved in stretch-receptor-mediated proprioception. It showed that trp-4 acts in a single neuron, DVA, to mediate its function in proprioception, and that the activity of DVA could be stimulated by body stretch.

Physiological aspects, Proprioception, Posture

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A ubiquitin ligase transfers preformed polyubiquitin chains from a conjugating enzyme to a substrate

Article Abstract:

Researchers have shown that ubiquitin chains can be preassembled on the catalytic cysteine of a conjugating enzyme (E2) before being transferred to a substrate. The characterization of the reactions might disclose additional examples of thiol-linked ubiquitin chains on E2 enzymes.

Post-translational modification, Ubiquitin-proteasome system

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