The K+/C1- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation

Article Abstract:

The main inhibitory transmitter GABA in the adult brain has a fast hyperpolarizing effect by activating anion C1--permeant GABAA receptors. GABAA-receptor-mediated responses are often depolarizing during early neuronal development. This may be an important factor in the control of certain Ca(super2+)-dependent developmental phenomena. Ontogenetic changes in GABAA-mediated responses in pyramidal neurons of the rat hippocampus, from depolarizing to hyperpolarizing were found to be coupled to developmental induction of the expression of C1--extruding K+/C1- co-transporter, KCC2. It is concluded that KCC2 is the main C1- extruder in promoting fast hyperpolarizing postsynaptic brain inhibition.

Hippocampus (Brain)

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Expression cloning of GABA(sub B) receptors uncovers similarity to metabotropic glutamate receptors

Article Abstract:

Gamma-amino-butyric acid (GABA) is the principal inhibitory neurotransmitter in the brain. It signals through ionotropic (GABA(sub A)/GABA(sub B)) receptor systems. In cloning GABA(sub B) receptors, the cloned receptors correspond to two highly conserved GABA(sub B) receptor forms present in the vertebrate nervous system. The cloned receptors negatively couple to adenylyl cyclase and reveal sequence similarity to the metabotropic receptors for the excitatory neurotransmitter L-glutamate.

Cover Story, Cloning, Glutamate, GABA receptors

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