The circumsporozoite protein is an immunodominant protective antigen in irradiated sporozoites

Article Abstract:

The circumsporozoite protein (CS) transgenic mice, which are tolerant to CS T-cell epitopes, are produced to study the role of non-CS antigens in protection. The protection induced by immunization with two doses of irradiated sporozoites (IrSp) is greatly reduced in the absence of T-cell dependent immune response to CS, but sterile immunity can be obtained by immunization of CS transgenics with three doses of IrSp.

New York, Physiological aspects, Polymerase chain reaction, T cells, Sporozoa

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Optimization of specificity in a cellular protein interaction network by negative selection

Article Abstract:

Negative domain-ligand selection can have a powerful function in optimizing protien interaction network specificity. The power of negative selection has previously been recognized in immunology.

Research and Development in the Physical, Engineering, and Life Sciences, Immunology

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Shape-shifting protein channel

Article Abstract:

The X-ray crystal structure of the SecYEB ion channel, a heterotrimeric protein translocase, and its functionality is depicted.

United States, Protein structure

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