The histone deacetylase RPD3 counteracts genomic silencing in Drosophila and yeast

Article Abstract:

The genomic silencing increases with loss of RPD3 function in both Drosophila and yeast indicating that RPD3 counteracts genomic silencing. A mutation in a Drosophila gene, which is similar to the transcriptional regulator RPD3 in yeast and a human histone deacetylase, show increased position-effect variegation (PEV). PEV is a result of mosaic inactivation of genes. A rpd3 null allele, in yeasts, increases telomeric silencing. These show that RPD3 is involved in countering the genomic silencing. The function of RPD3 may depend on the specialized chromatin structure of these loci.

Drosophila

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The transcription factor Ifh1 is a key regulator of yeast ribosomal protein genes

Article Abstract:

Ribosomal protein (RP) genes in eukaryotes are coordinately regulated in response to growth stimuli and environmental stress, thereby permitting cells to adjust ribosome number and overall protein synthetic capacity to physiological conditions. It is stated that Ifh1 association with promoters is the key regulatory step for coordinate expression of RP genes as transcription factors Fhl1 and Ifh1 associate almost exclusively with RP promoters.

Science & research, Genetic aspects, Eukaryotes, Ribosomal proteins

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TBP-associated factors are not generally required for transcriptional activation in yeast

Article Abstract:

The transcription of many genes is activated in yeast mutants lacking the TATA-binding protein-associated factors (TAF). The activation of transcription by the Gcn4, Ace1, Gal4 and Hsf promoters, and promoters of ded1 and his3 + 13 transcription is unaffected by the TAF mutations. However, genetic transcription is impaired in cells that lack the TFIID transcription factor.

Physiological aspects, Gene mutations, Gene mutation, Genetic transcription, Transcription (Genetics), Yeast, Yeast (Food product)

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