The human RNA kinase hClp1 is active on 3' transfer RNA exons and short interfering RNAs

Article Abstract:

The kinase human Clp1 (hClp1) has phosphorylated and licensed synthetic short interfering RNAs (siRNAs) to become assembled into the RNA-induced silencing complex (RISC) for subsequent target RNA cleavage. The physiological role of hClp1 is revealed as the RNA kinase that phosphorylates the 5' end of the 3' exon during human transfer RNA (tRNA) splicing, which allows the subsequent ligation of both exon halves by an unknown tRNA ligase.

Analysis, Genetic aspects, Exon (Molecular genetics), Exons (Molecular genetics), Structure, Phosphotransferases, RNA interference

---

A small-molecule screen in C. elegans yields a new calcium channel antagonist

Article Abstract:

Small-molecule inhibitors of protein function are powerful tools for biological analysis and can lead to the development of new drugs. Caenorhabditis elegans can provide a platform for both the discovery of new bioactive compounds and target identification.

Bacterial proteins

---

Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu

Article Abstract:

The article discusses the antiviral activity possessed by human cells that consist of the protein-based tethers, tetherins. The findings show that these tetherins inhibit retrovirus release and is highly antagonized by the HIV-1 accessory protein, Vpu.

Usage, Drug therapy, Protein metabolism, Retrovirus infections

Similar abstracts:

• Abstracts: The nonlinear nature of friction. Hurricanes and butterflies. Friction in a spin
• Abstracts: Odd company. Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP. A dark jet dominates the power output of the stellar black hole Cygnus X-1
• Abstracts: The nature of the hydrated excess proton in water. Tunnelling and zero-point motion in high-pressure ice. Anisotropy of earth's D" layer and stacking faults in the MgSiO(sub 3) post-perovskite phase
• Abstracts: Effects of spatiotemporal scale on autocorrelation and home range estimators. The effect of scent marking, forest clearing, and supplemental feeding on moose-train collisions
• Abstracts: Survival times of anomalous melt inclusions from element diffusion in olivine and chromite. Ultrafast superheating and melting of bulk ice

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.