The nuclear receptor homologue Ftz-F1 and the homeodomain protein Ftz are mutually dependent cofactors

Article Abstract:

The mechanisms that regulate the fushi tarazu (ftz)-encoded FTz protein which modulates engrailed (en) and wingless (wg) gene expression were analyzed in Drosophila eggs during oogenesis. Analysis of Drosophila en and wg gene expression during P-element mutagenesis in Drosophila eggs indicated the role of alphaFTz-F1 orphan nuclear receptors in mediating FTz-mediated modulation of en and wg gene expression. On the other hand, the transcriptional activity of the FTz-F1 gene was also modulated by FTz.

Physiological aspects, Genetic regulation, Genetic transcription, Transcription (Genetics), Cell receptors, Oogenesis

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Induction of germ cell formation by oskar

Article Abstract:

The oskar gene in Drosophila dominates the formation of germ plasm to the extent of determining how many germ cell precursors will develop at the embryo's posterior pole. The finding that experimental mislocalization of oskar RNA to the anterior pole induces germ cells at the anterior confirmed oskar's role in development. Although eight genes are required for germ cell creation at the posterior, only the oskar, vasa and tudor genes are indispensable at an ectopic site.

Developmental genetics, Germ cells

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Splicing of oskar RNA in the nucleus is coupled to its cytoplasmic localization

Article Abstract:

Oskar messenger RNA localization at the posterior pole of the Drosophila oocyte is essential for germline and abdomen formation in the future embryo. It is shown that splicing the first exon-exon junction of oskar RNA is essential for mRNA localization.

United States, Science & research, RNA

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