The nuclera RNase 3 Drosha initiates microRNA processing

Article Abstract:

RNase III, RNase III, human Drosha, as the core nuclease that executes the initiation step of microRNAs (miRNAs) processing in the nucleus is identified experimentally. miRNAs are transcribed as long primary transcripts (pri-miRNAs) whose maturation occurs through sequential processing events

Nucleases

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Intronic microRNA precursors that bypass Drosha processing

Article Abstract:

The identification of an alternative pathway for microRNA (miRNA) biogenesis, in which certain debranced introns mimic the structural features of pre-miRNAs to enter the miRNA-processing pathway without Drosha-mediated cleavage is presented.

Identification and classification, RNA, Life, Origin of life

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RNA rules

Article Abstract:

Recent studies show that the genome-wide DNA rearrangements during sexual reproduction are guided and ruled by an RNA template. The study has proved to reveal a new subject in the expanding world of the RNAs.

Genomic imprinting

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