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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

The oncoprotein Evi-1 represses TGF-beta signalling by inhibiting Smad3

Article Abstract:

A zinc finger protein with possible involvement in leukaemic transformation of haematopoietic cells is encoded by Evi-1. An investigation was undertaken on the effects of Evi-1 on signalling through transforming growth factor-beta (TGF-beta). Evi-1 is shown to repress TGF-beta signalling and antagonize the growth-inhibitory effects, defining a new function of Evi-1 as a signalling repressor through TGF-beta.

Author: Matsuyama, Tomohiro, Matsumoto, Kunihiro, Chiba, Shigeru, Hirai, Hisamaru, Yazaki, Yoshio, Kurokawa, Mineo, Takahashi, Tokiharu, Mitani, Kinuko, Irie, Kenji
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998

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Dishevelled controls cell polarity during Xenopus gastrulation

Article Abstract:

Xenopus dishevelled (Xdsh) is known to play many roles during embryogenesis and its inhibition disrupts convergent extension movements during gastrulation. New research using time-lapse confocal microscopy shows that failure of convergent extension in cells lacking Xdsh is due to defects in cell polarity.

Author: Wallingford, John B, Rowning, Brian A, Vogeli, Kevin M, Rothbacher, Ute, Fraser, Scott E, Harland, Richard M
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
Genetic aspects, Gastrulation

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WNT signalling molecules act in axis formation in the diploblastic metazoan Hydra

Article Abstract:

Research is presented concerning the function of the Wnt/wingless secreted proteins in the long-range organization and short-range inducement of tumorigenesis, organogenesis and axis formation in developing tissues.

Author: Rothbacher, Ute, Hobmayer, Bert, Rentzsch, Fabian, Kuhn, Kerstin, Happel, Christoph M., von Laue, Chrisoph Cramer, Snyder, Petra, Holstein, Thomas W.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
Cover Story, Physiological aspects, Letter to the Editor, Hydra, Hydras, Budding, Grafting (Horticulture)

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Subjects list: Research, Proteins, Carcinogenesis
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