The receptors DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing
Article Abstract:
Antigen-presentation factors of dendritic cells and thymic cells is associated with a high level expression of DEC-205. DEC is an integral membrane protein homologous to the macrophage mannose receptor and is capable of binding carbohydrates and mediate endocytosis. Test showed that the dendritic cells presented rabbit anti-DEC-205 to the T-cell clones two orders of magnitude more efficiently than the non-immune rabbit IgG-peptide. DEC-205 is rapidly taken up by means of coated pits and vesicles and delivered to a multivascular endosomal compartment that resembles the MHC class II-containing vesicles.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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Developmental regulation of MHC class II transport in mouse dendritic cells
Article Abstract:
Dendritic cells (DCs) can initiate primary and secondary immune responses, acquiring antigens in peripheral tissues and migrating to lymphoid organs, presenting processed peptides to T cells. The features of DC maturation are investigated by in vitro and in situ reconstitution of the terminal differentiation of mouse DCs. It was found that early DCs feature a phenotype in which class II molecules are intracellular, giving rise to a new intermediate phenotype upon maturation, where intracellular class II molecules are found in peripheral non-lysosomal vesicles.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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Dendritic cells and the control of immunity
Article Abstract:
Immunological research has established techniques to isolate and collect dendritic cells for study purposes. Dendritic cells are an intrinsic part of the immune system. They have several functions including the expression of lymphocyte co-stimulatory molecules and cytokine secretion. Further research is required to establish more information about specific dendritic cell functions in biochemical processes such as transcription.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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