The serepin PAI-1 inhibits cell migration by blocking integrin alpha(sub-v)beta(sub-3) binding to vitronectin
Article Abstract:
Vitronectin has a significant enhancing effect on the migration of smooth muscle cells and the specific vitronectin receptor alpha(sub-v)beta(sub-3) is necessary for cell motility. The alpha(sub-v)beta(sub-3) attachment site of vitronectin overlaps with the binding site for plasmINNgen activator inhibitor-1 (PAI-1). The active conformation of PAI-1 inhibits the migration of smooth muscle cells, an effect which necessitates high-affinity binding to vitronectin. PlasmINNgen activator localization at focal contact sites does not result in a proteolytic movement towards generalized matrix destruction.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Setting death in motion
Article Abstract:
Cell motion is necessary to embryonic development and continues to be important throughout life. The immune system constantly checks for infectious pathogens, and this process is controlled by chemokines. However Herbein and colleagues and Hesselgesser and colleagues report that chemokines can also act as death signals. Subversion of such signals by the human immunodeficiency virus (HIV) may be involved in the development of disease.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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Keeping the beat
Article Abstract:
The timing mechanisms that regulate the undulating beat of eukaryotic flagella and cilia are ill understood but models show that the underlying metronome effect requires a complex structure known as the axoneme. A new study indicates that oscillatory movements may be generated by simple sub-structures of the axoneme, which consists of some 250 poplypeptide components that include nine doublet microtubules arranged in parallel.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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