The transcription factor engrailed-2 guides retinal axons
Article Abstract:
Engrailed-2 (En-2), a homeodomain transcription factor is expressed in a caudal-to-rostral gradient in the developing mid-brain, where it has an instructive role in patterning the optictectum, the target of topographic retinal input. The differential guidance of nasal and temporal axons reported suggests that En-2 may participate directly in topographic map formation in the vertebrate visual system.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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Spatiotemporal dynamics of RhoA activity in migrating cells
Article Abstract:
The fluorescent biosensor is used, based on a novel design preserving reversible membrane interactions, to visualize the spatiotemporal dynamics of RhoA activity during cell migration. The RhoA activity is concentrate in sharp band directly at the edge of protrusions, in randomly migrating cells.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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