The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment

Article Abstract:

It is shown that a point mutation in the zinc finger transcription factor 'Th-POK' is responsible for redirection of class-II restricted thymocytes to the CD8 lineage in helper deficient (HD) mice. It is also demonstrated that consecutive expression of the factor during thymic development leads to redirection of class-I-restricted thymocytes to the CD4 lineage, which indicates that 'Th-POK' is a master regulator of lineage commitment.

Genetic transcription, Transcription (Genetics), CD4 lymphocytes

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Unique physiological and pathogenic features of Leptospira interrogans revealed by whole genome sequencing

Article Abstract:

The complete genomic sequence of a representative virulent serovar type strain of Leptospira interrogans serrogroup Icterohaemorrhagiae, consisting of large and small chromosomes, is reported. A comprehensive analysis for chemotaxis/motility and lipopolysaccharide synthesis provides a basis for in-depth studies of virulence and pathogenesis.

Gram-negative bacteria, Genomes

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Histone demethylation by a family of JmjC domain-containing proteins

Article Abstract:

A novel JmjC domain-containing protein, JHDM1 (JmjC domain-containing histone demethylase 1), is purified, which specifically demethylates histone H3 at lysine 36 (H3-K36). The results identify the JmjC domain as a demethylase signature motif and uncover a protein demethylation mechanism that is conserved from yeast to human.

Histones, Protein research, Lysine

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