Three-dimensional structure of the kinesin head-microtubule complex

Article Abstract:

The three-dimensional structure of the complex of a recombinant kinesin head and microtubules using helical reconstruction from cryo-electron micrographs is found to be a globular teardrop-like structure bound to the ridge of a protofilament of microtubules. Polarity of the structure of the complex and the kinesin head with respect to the microtubule polarity is determined.

Usage, Electron microscopy, Microtubules

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FGF-induced vesicular releases of Sonic hedgehog and retinoic acid in leftward nodal flow is critical for left-right determination

Article Abstract:

The fibroblast growth factor (FGF) is described to signal triggers secretion of membrane-sheathed objects 0.3-5 mu(m) in diameter termed 'nodal vascular parcels' (NVP) that carry Sonic hedgehog and retinoic acid. The results suggest that NVP flow is a new mode of extracellular transport that forms a left-right gradient of morphogens.

Science & research, Observations, Morphogenesis, Fibroblast growth factors

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Processivity of the single-headed kinesin KIF1A through biased binding to tubulin

Article Abstract:

Research has been conducted on unconventional kinesin (KIF1A) which moves as an independent monomer and works as a functional dimer. The authors have demonstrated that ATP hydrolysis triggeres a single stepping movement of the single KIF1A monomer.

Japan, All Other Basic Organic Chemical Manufacturing, Vinyl Chloride Monomer, Analysis, Physiological aspects, Tubulins, Tubulin, Adenosine triphosphate, ATP, Hydrolysis, Monomers, Binding proteins

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