Three-dimensional atomic model of F-actin decorated with Dictyostelium myosin S1
Article Abstract:
The description of the molecular contacts between actin and myosin is important for comprehending the force-generating process in muscle and other cells. An atomic model for the actomyosin complex, produced by the combination of atomic-X-ray structure of F-actin3, 4 and chicken myosin S1(5), is a three dimensional structure, reconstructed from electron micrographs of frozen-hydrated F-actin, decorated with recombinant Dictyostelium myosin S1. The model reveals the precise positions of actin and myosin molecules.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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Myosin-V is a processive actin-based motor
Article Abstract:
Class-V myosins have been implicated in many forms of organelle transport, and such movements may need a motor with mechanochemical characteristics distinct from myosin-II. It is proposed that myosin-V could be a processive motor, and a study provides evidence that it is a processive actin-based motor, and can move in large steps. Prolonged contact between myosin-V and its actin track may underpin its proposed role as an organelle tether.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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Molecular engineering of a backwards-moving myosin motor
Article Abstract:
The engineering of an artificial backwards-moving myosin from three pre-existing molecular building blocks is described. The result is that reverse-direction movement of myosins can be achieved simply by rotating the direction of the lever arm 180 degrees.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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