Thumbs up for inactivation

Article Abstract:

An unusual mechanism by which Ras-family proteins can be inactivated is revealed through new structural information. The structure reveals the molecular mechanism by which the GTPase-activating protein (GAP) induces guanine nucleotide triphosphate (GTP) hydrolysis and why cancer-causing mutations in Ras render the protein incapable of being inactivated.

Influence, Ras genes

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A receptor unlocked

Article Abstract:

The structure and the biological functions of the G-protein-coupled receptors (GPCRs) that govern several biological functions are discussed. The G proteins are found to control various processes, including metabolic activity and cell movement.

Metabolism, Epinephrine, Adrenergic receptors, Structure

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Proton-sensing G-protein-coupled receptors

Article Abstract:

Ovarian cancer G-protein-coupled receptor 1 (OGR1), previously described as a receptor for sphingosylphosphorylcholine, acts as a proton-sensing receptor stimulating inositol phosphate formation is shown.

Care and treatment, Ovarian cancer

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