Calcium activation of Ras mediated by neuronal exchange factor Ras-GRF

Article Abstract:

Ras in vivo appears to activate in response to neuronal exchange factor Ras-GRF's exposure to Ca2+ as well as activating through the accepted tyrosine kinase receptor pathway. The activation link to Ca2+ indicates that Ras-GRF may be involved in the regulation of Ca2+ influenced neuronal functions. Calmodulin appears responsible for mediating Ras activation through binding to an IQ motif.

Developmental neurology, Ras genes

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BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis

Article Abstract:

The pro-apoptotic BCL-2 family protein BAD is essential for the assembly of a functional holoenzyme complex along with protein kinase A and protein phosphatase 1 and two other proteins. Research shows that BAD mediates the regulation of glucokinase activity as well. Together, data indicate that BAD integrates pathways of glucose metabolism and apoptosis.

United States, Cellular control mechanisms, Cell regulation, Survival after airplane accidents, shipwrecks, etc., Survival, Glycolysis, Apoptosis

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Towards a molecular understanding of adaptive thermogenesis

Article Abstract:

Adaptive thermogensis is attracting more and more attention as a target for the development of antiobesity therapies. Basic research must still address a number of questions, including the identity of the dominant thermogenic mechanisms in human muscle.

Obesity, Thermogenesis

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