Trans-activation of group II intron splicing by nuclear U5 snRNA

Article Abstract:

The role of the ID3 subdomain stem-loop structure of group II introns in splicing the group II intron bI1 from yeast mitochondria was investigated. The subdomain ID3 was thought to be essential for 5' splice site recognition and anchoring of the free 5' exon(super 6). Without ID3, the 5' splice site was accurately and efficiently recognized but exon anchoring was significantly reduced. However, exon anchoring was restored in the presence of RNA fragments comprised of either the ID3 or spliceosomal U5 small nuclear RNA, suggesting that the primary role of both RNAs is to anchor the 5' exon during exon ligation. ID3 and spliceosomal U5 snRNA also appeared to be functional counterparts.

Analysis, RNA splicing, Introns

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Membrane tumour necrosis factor-alpha is involved in the polyclonal B-cell activation induced by HIV-infected human T cells

Article Abstract:

An experiment shows the possibility of the polyclonal B cell activation in HIV-infected subjects, mediated through the non-antigen-specific, MHC unrestricted membrane TNF-alpha-mediated pathway. The features of hypergammaglobulinaemia and the polyclonal B-cell activation is explained by the TNF-alpha pathway. HIV-infected T cells' continuous stimulation of the B-cell by the TNF-alpha pathway membrane causes B-cell malignancies in HIV-infected patients.

Research, Influence, HIV infection, HIV infections, B cells

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Genomic rearrangement in NEMO impairs NF-kB activation and is a cause of incontinentia pigmenti

Article Abstract:

Most cases of incontinentia pigmenti, a genodermatosis that segregates as an X-linked dominant disorder, are due to mutations of the factor VIII locus. A new genomic rearrangement is responsible for 80% of new mutations.

Causes of, Genetic aspects, Genetic disorders, Pigmentation disorders

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