Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain

Article Abstract:

Research indicates that the shift in the transmembrane anion gradient reverse the inhibitory anionic synaptic currents to be excitatory, which enhances the net excitability of lamina I neurons in rats. Data show that blocking potassium chloride exporter reduces the nociceptive threshold, validating the cause of neuropathic pain due to disruption of anion homeostasisin lamina I neurons.

Neurons, Ion channels, Neurotransmitters, Membrane potentials, Membrane potential

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UDP acting at P2[Y.sub.6] receptors is a mediator of microglial phagocytosis

Article Abstract:

Research study to show that microglia expresses the metabotropic P2[Y.sub.6] receptor whose activation by endogenous agonist UDP triggers microglial phagocytosis is conducted. UDP facilitated the uptake of microspheres in a P2[Y.sub.6]-receptor-dependent manner, which is mimicked by the leakage of endogenous UDP when hippocampal neurons are damaged by kainic acid in vivo and in vitro.

Phagocytosis

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P2X (sub)4 receptors induced in spinal microglia gate tactile allodynia after nerve injury

Article Abstract:

The authors discuss the study of pain caused by nerve damage. The authors report that pharmacological blockage of spinal P2X (sub)4 receptors reverses tactile allodynia induced by peripheral nerve damage and suppresses acute pain behaviours in animals.

Japan, Prevention, Behavior, Animal behavior, Animals, Neurophysiology, Pathology, Animal behaviour, Nerves, Peripheral, Peripheral nerves

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