Triggering positive competition

Article Abstract:

An ingenious fluorescence spectroscopy is used to follow the trigger factor dynamically as it interacted with the ribosome and a nascent polypeptide. It is found that when trigger factor binds to the ribosome it undergoes conformational rearrangements and acquires an open activated form that can adhere to hydrophobic patches on the polypeptide, indicating that there is a continuous supply of trigger factor to protect a nascent chain.

Israel, Analysis, Physiological aspects, Ribosomes, Polypeptides, Spectra, Fluorescence spectroscopy, Hydrophobic effect

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Vascular respiratory uncoupling increases blood pressure and atherosclerosis

Article Abstract:

Mice with doxycycline-inducible expression of uncoupling protein-1 (UCP1) in the artery wall is generated to test the hypothesis that inefficient metabolism in blood vessels promotes vascular disease. The results revealed that UCP1 expression in aortic smooth muscle cells causes hypertension and increases dietary arteriosclerosis without affecting cholesterol levels

United States, Hypertension, Causes of, Blood pressure

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A SNARE-adaptor interaction is a new mode of cargo recognition in clathrin-coated vesicles

Article Abstract:

Molecular studies of a new class of type II transmembrane proteins, soluble NSF attachment protein receptors (SNAREs) are described. The results help to understand assembly of SNAREs into clathrin-coated vesicles.

Clathrin

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