Tyrosine kinase-dependent selection of transmitter responses induced by neuronal contact
Article Abstract:
The action of a cytoplasmic signal causes the crammed channels to be insensitive to activation of protein kinase C when a microelectrode with an isolated membrane patch containing channels from an uninnervated target neuron is 'crammed' into a cell contacted by a presynaptic partner. The loss of channel modulation is prevented by the treatment of the neurons with selective inhibitors of tyrosine kinases. Early functional changes during specific synapse formation, that are induced by neuronal contact, are mediated by tyrosine kinases.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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Structure of an SH2 domain of the p85-alpha subunit of phosphatidylinositol-3-OH kinase
Article Abstract:
The src-homology 2 (SH2) domain from the 85K regulatory subunit of phosphatidylinositol-3-OH kinase is structured with a central beta-sheet, two alpha-helices on either side and a pliable loop close to functionally significant residues. The SH2 domain is important because it assists the protein-tyrosine kinase receptors in effecting cellular signalling. The SH2 domain's structure was verified using multidimensional nuclear magnetic resonance spectroscopy.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
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Axl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growth-arrest-specific gene 6
Article Abstract:
Immunoprecipitation technique helps isolate a novel stimulatory factor of Axl receptor tyrosine kinase. The activator is a protein encoded by growth-arrest-specific gene 6 (Gas6) and is dependent on vitamin K for its activity. Gas6 may play a role in growth regulation by Axl binding, which also induces proliferation.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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