Vertebrate embryo handedness

Article Abstract:

A temporary left-right asymmetry is detectable in bird embryos before the formation of organ systems based on the chick Hensen's node but this asymmetry gives way to symmetric structures within two to three hours. This characteristic may be indicative of a hidden primary asymmetry that guides the developmental mechanisms and may be responsible for inconsistent asymmetries between organs. Of 75 chick embryo blastoderm cultures, all showed normal node handedness until the 13-somite stage when six embryos developed situs inversus and seven had unclear handedness.

Left- and right-handedness, Handedness

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Induction and all that

Article Abstract:

The developmental biology of the frog Xenopus was the subject of an international conference held in Pacific Grove, CA, Jun 4-7, 1992. Topics discussed included the most recent research on the inductive intercellular signalling system believed to control growth of the frog's axial body plan and the cell-mechanical and gene activities associated with the development of the nervous system. The role of subregionalization of animal hemispheres in relation to cellular response to activin remained a highly disputed point.

Conferences, meetings and seminars, Growth, Xenopus

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Dismantling the organizer

Article Abstract:

The biochemical pathway of organizer formation can be explored by selectively removing gene products and seeing the impact when double negative offspring are bred. The removal of the homeobox gene Lim1 from mice resulted in embryos without anterior head structures though they had normal tail and trunk development, demonstrating both that the head and trunk and tail organizing centers are separate and that the homeobox gene is essential for the biochemical pathway.

Genetic aspects, Mice as laboratory animals, House mouse, Animal anatomy

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