Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors

Article Abstract:

Cues in the extracellular environment of the nervous system guide migrating cells and axons to their targets. Netrins are cues that can function as attractants and repellents. In Caenorhabditis elegans, UNC-5, a transmembrane protein, has been implicated in certain responses, with the loss of unc-5 function leading to migration defects. A report identifies two UNC-5 vertebrate homologues, defining a new immunoglobulin subfamily. This indicates that the UNC-5 homologues and the mouse rostral cerebellar malformation gene are netrin-binding proteins.

Central nervous system, Immunoglobulins, Neurophysiology

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Neural regulation of thermotaxis in Caenorhabditis elegans

Article Abstract:

An amphid sensory neuron is an important thermosensory neuron and the interneurons AIY and AIZ are responsible for thermophilic and cryophilic movement, respectively, the regulation in opposite direction of which is necessary for thermotaxis. Thermal stimulus is a major factor that influences animal behavior. In Caenorhabditis elegans, the range in the ability to recognize temperature changes is high providing an ideal system to study the cellular and molecular processes in thermosensation and thermal information storage.

Cold adaptation

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Diverse behavioural defects caused by mutations in Caenorhabditis elegans unc-43 CaM Kinase II

Article Abstract:

It has been established that unc-43 encodes the only Caenorhabditis elegans calcium/calmodulin-dependent serine/threonine kinase type II (CaMKII). Mutations in the unc-103 potassium channel gene suppress a gain-of-function phenotype of unc-43 in one tissue without having an impact on other tissues. UNC-103 may therefore be a tissue-specific target of CaMKII in vivo. It is likely that the nematode CaMKII mediates cell excitability through both modulation of channel activity and modelling of the synapse.

Potassium channels, Protein kinases

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